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Bile-Salt Binders:

These drugs bind with bile salts, a normal product of the liver. Bile salts flow from the liver to the intestine and aid in digesting fat. On average, 90 to 99 percent of the bile salts are reabsorbed by the ileum and recycled. The remainder 1 to 10 percent is lost in the stool when it reaches the colon and does not cause any problems. However, if the ileum is diseased or absent, more of the bile salt reaches the colon and the excess irritates the lining of the colon. Diarrhea is usually what happens when not enough bile salt is reabsorbed. Bile-salt binders can prevent the irritation.

Bile-salt binders are sometimes for a patient with ileal disease or previous ileal resection. Diarrhea controlled by other antidiarrheals is perfectly acceptable.

Side effects of bile-salt binders may include difficulty digesting and absorbing fat, nausea, vomiting, constipation, abdominal pain, and bloating. Cholestyramine is available as a powder that does not dissolve in anything and has a metallic taste. Because of its inconvenience and unpalatable nature, many physicians prefer to use loperamide or other antidiarrheals.

See related articles:
Crohn's Disease Information
Drug Therapy for Crohn's Disease
Drugs that Reduce Inflammation
Drugs that Treat Symptoms

Drug Therapy articles:
5-ASA (5-Aminosalicylate)
Antibiotics for Crohn's Disease
Bile-salt Binders
Bulk Formers
Immunosuppressive Drugs
Steroids for Crohn's Disease
Sulfasalasinze for Crohn's Disease

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